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Document History Version: V 1.0 Author: SWL ICB Approved by: Integrated medicines committee (IMOC) Approval date: 16/11/2022 Review Date: 2 years from approval date or sooner where appropriate

It may therefore interfere with methylation- dependent metabolism and indicate poor flow through the methionine cycle

Beyond the intestinal mucosa, VDR is present in tissues such as the kidney, skin, pancreas, and placenta, where it regulates functions ranging from electrolyte balance to insulin secretion

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A few small human trials have been conducted, primarily for inflammatory bowel disease

This is an especially quick way to get the vitamin straight into the bloodstream, and is typically used to battle megaloblastic anemia