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This remains an open question for all senolytic therapies, not just FOXO4-DRI

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Al-Majed AA, Sayed-Ahmed MM, Al-Yahya AA, Aleisa AM, Al-Rejaie SS, Al-Shabanah OA: Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model

This cataploretic step promotes acetyl-CoA accumulation in the cytoplasm and favors acetylation of cytoplasmic proteins