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GPX4 protein level is regulated transcriptionally by transcription factor SP2 or Nrf2

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In a medically supervised, quality-controlled context with appropriate screening and protocol design, it is generally viewed as a reasonable regenerative strategy and is commonly reported as well tolerated

10.1185/03007998809110456 61 CaroneL.OxberryS

In that study, transplanted HSCs infiltrated areas characterized by damaged cells and neuroinflammation, acquiring an immunomodulatory cellular phenotype, but ALS patients did not show any clinical benefits ([139]