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Practical Considerations: Sequencing, Dosing, and Provider Guidance Most providers continue metformin during semaglutide initiation, as metformin is typically first-line in type 2 diabetes and does not interfere with GLP-1 therapy

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Second, GIP signaling appears to improve fat tissue biology by enhancing lipid storage in appropriate adipose depots rather than ectopic locations like the liver and muscle

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Pair strength training with protein intake To counteract the drugs effect on muscle mass and bone-density loss, strength training and protein intake are critical

By improving insulin sensitivity , regulating blood sugar, and reducing cravings, these medications help people regain control over their metabolic health