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Take the lowest effective dose : Starting with the lowest dose that provides relief may help decrease the risk of side effects from interactions

Feb 2014;122(2):115-9

Symptoms of Vitamin B12 Deficiency Extreme tiredness, headaches/migraines, indigestion, diarrhoea, loss of appetite, low energy and mood, muscle weakness, a sore or red tongue often with mouth ulcers, pins and needles, weakened vision

CHCHD2 mutations in autosomal dominant late-onset Parkinsons disease: a genome-wide linkage and sequencing study

It should be noted that parenteral choline, inositol, and methionine combinations are not licensed medicines in the UK

Stem cells may be more effective