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The distinction is not about targeting a different hormonal pathway, but rather about generating a different duration and pattern of hormonal signaling

Notably, research involving astrocytes cultured from a transgenic AD mouse model overexpressing apoE demonstrated that melatonin reversed the A aggregation-promoting activity of this protein [74]

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Studies have confirmed that CUL5 regulates the stability of key proteins involved in cholesterol metabolism through ubiquitination (71)

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