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Retatrutide is an investigational triple-hormone receptor agonist developed by Eli Lilly that targets three receptors: GIP (glucose-dependent insulinotropic polypeptide), GLP-1 (glucagon-like peptide-1), and glucagon

Laboratory studies investigate its mechanisms at the cellular level, including receptor binding, signal transduction, and gene expression pathways

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The paired Wilcoxon signed-rank test has a p-value of 0.06, which was the lowest possible p-value for the Wilcoxon signed-rank test given only five pairs of data