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This dual regulation of neurotrophic and insulin pathways may explain the significant neuroprotective effects seen with the combination, offering a mechanistic rationale for synergistic action rather than a merely additive benefit

significant elevations warrant dose reduction or discontinuation

Methylation levels of NLRP3, TGF1, MCP-1, and TNFSF2 are significantly lower in DR patients compared to healthy individuals, suggesting that hypomethylation of these genes contributes to DR progression [66]

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Trichuris suis therapy in crohn's disease