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Aschbacher K, Rodriguez-Fernandez M, van Wietmarschen H, et al

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The timeline is gradual: better sleep and energy at 4 weeks, less bloating and improved recovery at 8 weeks, measurable body composition changes by 12 weeks

Finally, TRANSCEND-T2D-3 (NCT06297603) will compare retatrutide to placebo over 14 months, in people with inadequately controlled T2D and moderate-or-severe renal impairment on basal insulin

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The pen delivery system allows consistent measurement within laboratory settings, supporting accurate evaluation of dose-response behaviour and compound interaction under structured research conditions