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Although we performed multivariate adjustments, residual confounding may persist due to unmeasured factors such as dietary habits (e.g., irregular intake of animal-derived foods or B12-fortified products), unrecorded use of nutritional supplements, and genetic predispositionsparticularly MTHFR polymorphisms, which are known to influence homocysteine metabolism and folate cycling, thereby potentially altering the functional demand for vitamin B12

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10 Hydroxocobalamin, Methylcobalamin and L-Methylfolate for MTHFR Methylcobalamin is the most readily available and intracellularly active form of B12, and is relatively easy to find in supplements

Use of antacids Coadministration of antacids and this medicine may reduce the absorption of this medicine

Titrate: Increase by roughly 100 mcg per dose every two weeks as tolerated

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