Another possibility is the following: after uptake, vitamin B12 is slowly bound to serum vitamin B12 proteins ( The mechanism by which vitamin B12 administration exerts its positive effect on ME/CFS patients is unknown
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B Vitamins and the Brain: Mechanisms, Dose and Efficacy - A Review
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For those experiencing fatigue and weakness due to a Vitamin B12 deficiency, our injections offer a direct and rapid method to replenish this vital nutrient
They do not resemble migraines with aura or severe tension headaches