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A study published in a quality-of-life journal found that patients who switched from oral semaglutide to tirzepatide due to insufficient weight reduction experienced significant improvements in quality of life as early as 3 months after the switch

And if you have a personal or close family history of cancer, heart disease, liver disease, stroke, or blood clots (e.g., deep vein thrombosis, or DVT), then HRT may not be the safest to use, in general

10.1016/j.bbamcr.2012.02.019 77 PerissinottoE.BujaA.MaggiS.EnziG.ManzatoE.ScafatoE.et al (2010)

The risk with aggressive fat loss including GLP-1 class compound-driven fat loss is lean mass loss

We see this

Dermatol Ther (Heidelb) 11:833