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Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, Tugwell P: The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

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22,23 In general, TADs not only facilitate transcription initiation by combining with transcriptional coactivators and transcription machinery elements but also inhibit transcriptional activity by binding to negative regulators

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