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In a study of 12 million people with diabetes (4.6 million on GLP-1 medications and 7.4 million on other medications), researchers found substantially more delayed gastric emptying with the GLP-1 medications that were in use earlier, which are generally not used for obesity

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Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

Vitamin B12 is a water-soluble vitamin essential for energy metabolism, red blood cell formation, and neurological function, but has no licensed indication for weight loss in the UK

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In this context, incretin resistance might partially reflect a failure of signal compartmentalization: even when bulk cAMP rises, local RAiN/MERCS nanodomains may be unable to sustain effective signaling ( 2+ microdomain readouts) integrated with single-cell spatial profiling across age and disease severity (Manchanda et al., 2024)