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Alarmingly, the global incidence of gout has increased significantly in recent decades, particularly in the Western and AsiaPacific regions, underscoring the need for improved management strategies (Nakayama et al., 2023

Paradoxically, GLP-1 agonists can cause diarrhoea as a side effect in some people despite generally slowing gut transit

Together, these elements allow rapid conceptual interpretation (Figure 3) while maintaining transparency regarding the level of experimental and clinical support (Table 1)

Because of this, the gut often becomes a primary reservoir for the virus

25 A subsequent single-center placebo-controlled, multiple-ascending dose, phase 1b trial examined the safety, tolerability, pharmacokinetics, and pharmacodynamics of cagrilintide in combination with semaglutide

2024 Jul Office of Dietary Supplements, National Institutes of Health