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Early studies in obese individuals showed some reductions in body fat mass, but findings are not consistent across trials: In one clinical trial, AOD9604 did not demonstrate statistically significant weight loss compared to placebo, suggesting its fat-burning effects may be modest without lifestyle intervention (summary of trials)

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The bigger the container of water, the longer it may take

In contrast, B12 pills, even those labeled as 1000mcg, have an absorption rate of about 30%

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Nature 530 , 447 (2016)