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Epithelial PBLD attenuates intestinal inflammatory response and improves intestinal barrier function by inhibiting NF-B signaling

Patients with active thyroiditis or those experiencing thyroid storm should not begin GLP-1 therapy until the acute thyroid emergency resolves and hormone levels stabilize

In preclinical models this dual mechanism produced greater weight loss than a maximal semaglutide dose, and in a Phase 2 diabetes trial higher survodutide doses reduced weight more than semaglutide though human superiority has not been formally established in head-to-head registration trials

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Outcomes relied exclusively on caregiver-rated behavioral assessments using Rossago Behavioral Checklist