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CRISPR-mediated modifications Within the past decade, the advent of genome engineering with CRISPR-Cas9 has revolutionized gene therapy, opening a new therapeutic avenue based on DNA-level modifications

The peptide appears to act through direct interaction with adipocytes (fat cells), potentially involving activation of hormone-sensitive lipase (HSL) and modulation of -adrenergic receptor signaling pathways

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Elife (2016) 5:e17936

In ischemiareperfusion injury (IRI), which can lead to systemic inflammation, while reperfusion is important to restore blood flow so as to prevent irreversible tissue damage, the abrupt restoration of blood flow can paradoxically trigger an inflammatory cascade