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Researchers who escalated too quickly bore the brunt of gastrointestinal side effects, while those who followed the standard four-week titration intervals reported significantly better tolerability

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and Yadav, S

The declining plasma concentration provides a quantitative framework for researchers designing dose-response studies, as physiologically relevant in vitro concentrations should bracket the 200-500 nM range to model the young-to-aged spectrum

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Thelen, M