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mHtt can inhibit PGC1a expression at the transcriptional level to reduce mitochondrial biogenesis (Intihar et al., 2019), directly disrupt mitochondrial proteostasis through high-affinity binding with the mitochondrial inner membrane 23 (Yablonska et al., 2019), and affect the mitochondrial respiratory chain (Jdrak et al., 2018)

Refrigeration is not strictly required but is often preferred in laboratory settings to help support prolonged stability after opening

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Three different rodent diets (Table 1) were provided ad libitum to 20 animals each (Research Diets, Inc., New Brunswick, USA)

General inflammation and slow healing This is the broad bucket, and honestly it is the one most likely to lead to disappointment if expectations are not managed