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Blockade of D1-signaling also inhibited RANKL induced in vitro osteoclastogenesis in BMDM exposed to low levels of dopamine (10 7 M), an effect that was blocked by activating D1-like receptors with A68,930 (Nakashioya et al., 2011)

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Gastroenterology 146:497507.e1

Studies, including research from the National Institute on Drug Abuse (NIDA), show that repeated opioid exposure leads to structural brain changes, increasing the risk of addiction

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