A prespecified analysis of pooled data from the STEP-HFpEF and STEP-HFpEF DM trials demonstrated that significantly more patients treated with Wegovy 2.4 mg SC once weekly had an improvement of at least one in New York Heart Association (NYHA) functional class compared to those who received placebo (32.6% versus 21.5%, respectively
In addition, some studies on recently marketed GLP-1 RAs such as dulaglutide (AWARD studies), albiglutide (HARMONY studies), and lixisenatide (GetGoal studies) included cardiovascular parameters as a part of their non-primary endpoints (Table 2)
GLP-1 receptor agonists also exert antioxidant, anti-inflammatory, and antifibrotic effects by downregulating pro-inflammatory pathways (e.g., nuclear factor-B), cytokines (e.g., transforming growth factor ), and T-cell proliferation [18]
The American Thyroid Association guideline on levothyroxine dosing already recommends separating levothyroxine from other drugs and food by 30 to 60 minutes [8]
Clean the chosen site with an alcohol swab in a circular motion, starting from the center and spiraling outward
A 2025 study on liraglutide nanoparticles demonstrated successful transdermal delivery with sustained effects in early-stage testing
