In part 1a, four ascending dose groups were tested in a sequential design
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However, the reduction in HF hospitalisations with semaglutide did not reach statistical significance.9 The STEP-HFpEF DM randomised controlled trial enrolled 616 patients with obesity (BMI 30 kg/m 2 ) and both HFpEF (LVEF 40%) and T2D.37 STEP-HFpEF DM specifically investigated the effect of once-weekly subcutaneous semaglutide versus placebo on the primary endpoint of change in KCCQ-CSS at 52 weeks
