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This has important implications for muscle biology: GH-dependent skeletal muscle anabolism is partially dependent on pulsatile GH signalling for GHR internalisation-recycling kinetics, and sustained GH elevations (as produced by CJC-1295/DAC) generate a different GHR occupancy profile than pulsatile endogenous GH

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from three independent computational replicates

Because SLC7A11 regulates GSH synthesis (through intracellular cystine availability) and 15LO1 decreases intracellular GSH, a high SLC7A11 to 15LO1 protein ratio likely supports high/normal intracellular GSH

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