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GLP-1R, GIPR, and GCGR are all present in pancreatic cells

The hormones produced by the enzymatic processing of proglucagon then play essential roles in glucose metabolism and homeostasis [8, 9]

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As mentioned, GLP-1RAs are increasingly used in the treatment of T2MD owing to their following advantages: lowering of the levels of blood glucose, reducing body weight, improving the function of islet, and exerting potential cardiovascular benefits (206)