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Other causes, such as irritable bowel syndrome (IBS),14 inflammatory bowel disease (IBD), colonic neoplasms, and hyperplastic polyps, could also contribute to the onset of MC.13,15 Some studies show that MC may be connected to the use of non-steroidal anti-inflammatory drugs (NSAIDs),16 vitamin E (VE) deficiency, the intake of unsaturated fatty acids,17 environmental factors,18 family history,3 psoriasis19 and Rett syndrome.20 Feces stasis also plays an important role in the pathogenesis of MC

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Conversely, Wang et al

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Watch for any specks, fibers, crystals, or clumps floating in the solution or settled at the bottom

doi: 10.1038/s41598-019-38877-0 5 AlbornozK.ZhouJ.YuJ.BecklesD