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Disruption of this regulatory circuit, as observed in PD patients with lower heart rate variability (a sign of vagal dysfunction), causes exacerbated systemic inflammation and greater microglial priming once peripheral cytokines or endotoxins reach the CNS [121]

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468 Generalised astrocytic atrophy is also characteristic for alcoholism, in which astrocytes display loss of function, such as for example reduction in synthesis and secretion of thrombospondins