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In conjugation with the significant reduction in body weight, the weight of epididymal white adipose tissues was significantly reduced after treatment with 2.5 g/kg of KBP-089 and combinations of KBP-089 and liraglutide, whereas only the combination therapy significantly reduced the weights of inguinal and perirenal adipose tissue (Fig

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Over 25 years ago, Turton and Bloom demonstrated that icv GLP-1 acutely inhibited food intake in rats

Increasing the number of intestinal endocrine L-cells According to the impairment of L-cells development in T2DM, a promising strategy for treating T2DM is to increase the number of L-cells in the intestine, thereby increasing the production of GLP-1