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In addition to alterations in the mechanistic functions of brain endothelial cells, BBB breakdown is evident by degeneration of both endothelial cells and pericytes [101]

Hepatol Res 45(3):269278 Errafii K, Khalifa O, Al-Akl NS, Arredouani A (2022) Comparative transcriptome analysis reveals that Exendin-4 improves steatosis in HepG2 cells by modulating signaling pathways related to lipid metabolism

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Mixed reports indicate that EDTA does not cross the blood-brain barrier, but this is in contrast to reports that EDTA may cause increased symptoms of lead poisoning or mercurialism [87]

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