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In fact, these are the most challenging skin changes of aging

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Expression of E-cadherin cell adhesion molecules suppresses melanocyte proliferation, but on the other hand, expression of N-cadherin triggered by trauma or metabolic changes in the microenvironment promotes proliferation and migration of melanocytes, which can then aggregate in nests [4, 6]

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Pancreatic tumor was excised from the animal, minced in smaller pieces using sterile scissors and finally digested using a collagenase VI solution (2 mg/mL in DMEM/F12