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FDA Guidance for Industry: Human Growth Hormone and Related Biologics

Chapter Six - Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

The primary theoretical safety concern is sustained activation of the HGF/c-Met proto-oncogenic pathway, which could theoretically promote tumor initiation or growth

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The translation would be immune cells that could be given to patients undergoing surgery as a supportive immune boost that is resistant to the oxidative/inflammatory surgical milieu

Symptom monitoring: Fatigue, numbness or cognitive problems should improve with treatment