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The most common side effects are mild gastrointestinal issues, such as nausea, decreased appetite, or minor stomach upset, which usually subside as your body adjusts
But translating statistical superiority from randomized trials into real-world expectations requires more nuance
Fluge et al
It increases insulin sensitivity, boosts fat burning, and optimizes energy expenditure
Additionally, research presented at the American Academy of Orthopaedic Surgeons' 2026 annual meeting raised questions about bone and connective tissue effects in GLP-1 users more broadly
Cakmak and Kutman, 2018)
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