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Specifically, I was on tirzepatide

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Magnesium Glycinate: Often used to support relaxation and sleep, magnesium is generally well-tolerated and doesnt typically have the same blood sugar concerns as ashwagandha

Semaglutide operates through an entirely different mechanism by mimicking glucagon-like peptide-1 (GLP-1), a hormone that regulates blood sugar and appetite at the gut level

As for depression specifically In addition, the discovery that antagonists of the N-methyl-D-aspartate (NMDA) receptor, notably ketamine, produce rapid improvement in depressive symptoms (within hours), even in TRD patients, has shifted efforts towards novel agents targeting the glutamatergic system This is the future folks

One such molecule is rapamycin, an mTOR inhibitor