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Among the contenders, Eli Lillys retatrutide and Amgens MariTide are setting a new benchmark with weight reductions exceeding 24%, rivaling or surpassing bariatric surgery, an extraordinary feat in non-surgical treatment history

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doi:10.1016/j.peptides.2019.170202 18

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Some participants discontinued therapy due to perceived excessive weight loss

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Vomiting more than three times in 24 hours warrants a call to your healthcare team

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One to two HIIT sessions weekly can fit within most protocols, ideally separated from resistance training days

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Some research suggests that dual-agonist drugs like Zepbound may cause more GI side effects at higher dose strengths

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