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Accordingly, and in line with currently ongoing trials in HFpEF (ClinicalTrials.gov IDs NCT04916470 and NCT04788511), it may be relevant to consider obesity-related HFpEF as a specific (sub)phenotype, whether coexisting with type 2 diabetes or not

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Its diverse biological roles have positioned it as a key target for therapeutic interventions in diabetes and obesity

doi: 10.3389/fimmu.2025.1524711

Peptide drugs, on the other hand, are manufactured to last longer in the body to create a therapeutic response, such as controlling appetite or promoting the growth of new blood vessels, bone density or muscle