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Moreover, FOXO4-DRI was used to selectively induce apoptosis of senescent fibroblasts in both keloid fibroblast and organ culture senescent models, showing potential as a treatment that targets the senescence and apoptosis resistance observed in keloid fibroblasts

These molecules also serve normal signaling functions, but excess production can damage lipids, proteins, enzymes and DNA

For example, the administration of HPL to the lateral ventricles of rats subjected to focal ischemia induced by permanent distal middle cerebral artery occlusion significantly enhanced the proliferation of endogenous neural stem cells and angiogenesis in the SVZ and in the perilesion cortex and improved neurobehavioral outcomes

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UCLA Health)

doi:10.1016/j.joim.2018.11.004