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The potential of GLP-1RAs to induce psychiatric adverse events is biologically plausible given the widespread expression of GLP-1 receptors in the central nervous system, 167 their influence on neurocognitive function, 168 and their effects on inflammation, stress response, and energy metabolism, which theoretically could improve mood

But in this case, theres an huge amount of long-term safety data on these medications

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Review analysed evidence from 25 clinical trials Researchers conducted a systematic review and meta-analysis of 25 randomized controlled trials (RCTs) involving 8,069 participants (about two-thirds female and predominantly White)

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From 7.5 to 10 mg, GLP-1 engagement roughly doubles from the 5 mg level