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The impact of cancer cell migration on the lymphatic system The lymphatic vascular system is a low-pressure, unidirectional circulation system that plays a critical role in tissue fluid homeostasis, tissue regeneration, lipid absorption and transportation, as well as immune surveillance (43, 101)

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Opioids Opioids mask pain through central nervous system effects but carry risks of tolerance, dependence, overdose, and paradoxical opioid-induced hyperalgesia

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The synergy isn't additiveit's multiplicative, provided dosing timing prevents competitive inhibition at the cellular level