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Key Research Institutions & Investigators Novo Nordisk (developer and trial sponsor) University of Copenhagen (metabolic research center) Yale University (Dr

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The epigenome is highly responsive to various metabolic, cellular, and physiological signals [25, 26], and the immediate pre-pubertal period is clearly a particularly sensitive period for moderating SRD5A1 expression given that it is normally upregulated at this time, as seen also in other developmental genome-wide screens [86]

doi: 10.1016/j.bbagen.2013.09.017 123 MasiAFortiniPKrokidisMGRomeoEFBasciettoCDe AngelisPet al