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Ascorbic acid intake and oxalate synthesis

Can you help me understand the nuance here

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The third component of this triad is Methylsulfonylmethane (MSM) , a naturally occurring, highly bioavailable organic sulfur compound

Changes in CYP7A1 activity can upset the bile acid balance and interfere with liver metabolism (Low et al ., 2020)

The guidelines are for people at high risk to be screened with a routine blood test at least once a year