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Preliminary observations from a Phase III clinical trial (NCT02896192) suggested that among 10 patients with POMC -deficient obesity (aged 6 years, BMI 30 kg/m 2 ), approximately 80% achieved a weight reduction of 10% after 1 year of treatment with setmelanotide following individualized dose titration

Weight loss accelerates not in a straight line but in a curve, steeper through the middle months, then gradually flattening as the body reaches a new equilibrium

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