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However, at the same time that folate deficiency was largely eliminated in these populations, the prevalence of intake exceeding the Tolerable Upper Intake Level of folic acid intake (1 mg/d) increased substantially (6, 22), although this was attributed to the concurrent use of supplements and fortified ready-to-eat cereals rather than to fortification alone

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Fluorescence microscopy studies have documented rapid cellular accumulation, with detectable intracellular concentrations within 30 minutes of external application at physiological concentrations

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