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2) may eliminate a tolerogenic signal that is recognized by circulating regulatory T cells

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Norepinephrine and the control of food intake

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Studies generally report a weight loss of about 15-16% of initial body weight with Semaglutide, while Tirzepatide can result in a 14-18% reduction

Long-term protocols (6-12 months) can be used with enhanced tracking and periodic breaks, though continuous use beyond 6 months should include 1-2 week breaks every few months