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Key gaps No semaglutide trial programme publicly reports validated vaginal symptom patient-reported outcomes (dryness scales, dyspareunia scores, pH/microbiome endpoints) in regulatory product information, limiting incidence estimation for vaginal endpoints

Recent data suggests the risk may be greater than previously understood, particularly for people taking Wegovy, the higher-dose version of semaglutide used for weight loss

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Ensuring consistent fluid intake and adequate protein consumption often resolves early-onset fatigue within 24 weeks