TRT (Testosterone Replacement Therapy) for Hypogonadism R: Critical differences: hCG Intratesticular testosterone: maintained (spermatogenesis preserved) Testicular volume: preserved Fertility: maintained/restorable Frequency: 2-3x/week Cost: higher TRT Intratesticular testosterone: suppressed (atrophy, infertility) Testicular volume: reduced 30-50% Fertility: compromised Frequency: variable (daily-weekly depending on formulation) Cost: lower Choice: hCG if fertility/testicular function is important
It works by mimicking a hormone called GLP-1, which helps regulate blood sugar levels and reduce appetite
Whether this is three per year or a course of three or three in a lifetime is not at all clear and left to individual clinicians judgement and experience
Science 293, 10891093
[PMID: 31740394 DOI: 10.1016/j.ejps.2019.105158] [DOI] [PubMed] [Google Scholar] 69.Mardikian PN, LaRowe SD, Hedden S, Kalivas PW, Malcolm RJ
The standard of care for Traumatic Brain Injury (TBI) and concussion has long relied on a "software-centric" model: symptom management, cognitive rest, and rehabilitative therapy