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Scientific Research Fund of Binzhou Medical University (BY2021KYQD032), National Natural Science Foundation of China (grant number 82200981), Special Funds of Taishan Scholars Project of Shandong Province (grant number tsqn202312384), and the Natural Science Foundation of Shandong Province (grant number ZR2022QH358)
The risk of pancreatitis with GLP-1 agonist medications is well-documented, though the incidence remains very low (0.27% to 2.2%, depending on the study)
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On a unit-to-unit basis, TOUJEO had a lower maximum (GIRmax) and 24-hour glucose lowering effect (GIR-AUC0-24) compared to LANTUS
Further studies have found that hyperglycaemia can impair the antioxidant defence system by inhibiting Nrf2 activity, while GLP1RA can reverse this change by activating the Nrf2 signalling pathway to enhance antioxidant gene expression, thereby promoting ROS clearance
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