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Dual-pathway therapies that target both GLP-1 and GIP receptors sit alongside better-known GLP-1-focused options

Under physiological conditions, mitochondria localized near the apical membrane form a buffering zone that restricts the spread of Ca 2+ signals from the subplasmalemmal region to the cell interior, thereby protecting PACs from Ca 2+ -induced injury ( 2+ microdomains arising at close contact between the PM and mitochondria enable rapid mitochondrial Ca 2+ uptake, activation of TCA cycle enzymes, and stimulation of ATP production, a critical energy source for enzyme secretion and maintenance of electrolyte gradients ( 2+ indicators average signals over relatively large cytosolic volumes, whereas genetically encoded Ca 2+ sensors targeted to defined subcellular compartments are only beginning to be applied systematically in pancreatic models

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Diagnostic criteria for postconcussional syndrome after mild to moderate traumatic brain injury

Thus, GSH levels can become depleted as a result of poor diets or periods of fasting (for example, while we are sleeping)