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Meanwhile, TMAO can significantly upregulate the expression level of PIEZO1 and enhance the sensitivity of chondrocytes to mechanical loading, and this effect may be closely related to the pathogenesis of OA (Zhuang et al., 2023)

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Prediabetesdefined by fasting glucose between 100-125 mg/dL or HbA1c of 5.7-6.4%represents another pathway to GLP-1 eligibility