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in diabetic rodents, Fan and colleagues [77] demonstrated that intravitreal exedin-4 injection reduced retinal cell loss, maintained Bcl-2/Bax ratios, whose imbalance is associated with retinal cell apoptosis, prevented activation of pro-apoptotic AKT, and prevented excess reactive gliosis

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Hence, trials investigating GLP-1 agonists for weight management report higher gallbladder complication rates than diabetes-focused studies

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PMID: 17220370 Fernandez-Checa JC, Kaplowitz N