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In such cases, treatment options include: Treatment options for lip hyperpigmentation include topical depigmenting agents, laser therapies, chemical peels, and consistent use of sun protection to prevent further darkening

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Fan H, Li TF, Gong N, Wang YX (2016) Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis Rotata, reduces neuropathic pain by stimulating spinal microglial beta-endorphin expression